Combined Administration of Fibrinogen and Factor XIII Concentrate Does Not Improve Dilutional Coagulopathy Superiorly Than Sole Fibrinogen Therapy: Results of an In-Vitro Thrombelastographic Study

Combined Administration of Fibrinogen and Factor XIII Concentrate Does Not Improve Dilutional Coagulopathy Superiorly Than Sole Fibrinogen Therapy: Results of an In-Vitro Thrombelastographic Study

The early administration of fibrinogen has gained wide acceptance for the treatment of major hemorrhage, whereas the substitution of coagulation factor XIII (FXIII) is only supported by a low level of evidence. This study aimed to answer the question of whether a combined therapy of fibrinogen/FXIII...

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Bibliographic Details
Main Authors: Emmanuel Schneck, Marcus Muelich, Melanie Markmann, Fabian Edinger, Nina Cooper, Annette Moeller, Gregor Bein, Andreas Hecker, Christian Koch, Michael Sander, Matthias Wolff
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Journal of Clinical Medicine
Subjects:
hemorrhage
major bleeding
coagulation
thrombelastometry
impedance aggregometry
trauma
Online Access:https://www.mdpi.com/2077-0383/10/10/2068

Internet

https://www.mdpi.com/2077-0383/10/10/2068

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