Heterogeneous Tumor Subpopulations Cooperate to Drive Invasion

Clonal selection and transcriptional reprogramming (e.g., epithelial-mesenchymal transition or phenotype switching) are the predominant theories thought to underlie tumor progression. However, a “division of labor” leading to cooperation among tumor-cell subpopulations could be an additional catalys...

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Bibliographic Details
Main Authors: Anna Chapman, Laura Fernandez del Ama, Jennifer Ferguson, Jivko Kamarashev, Claudia Wellbrock, Adam Hurlstone
Format: Article
Language:English
Published: Elsevier 2014-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714005294