Interferon-α Up-Regulates the Expression of PD-L1 Molecules on Immune Cells Through STAT3 and p38 Signaling

Interferon-α Up-Regulates the Expression of PD-L1 Molecules on Immune Cells Through STAT3 and p38 Signaling

Interferon-α (IFNα) has one of the longest histories of use amongst cytokines in clinical oncology and has been applied for the treatment of many types of cancers. Due to its immune-activating properties, IFNα is also an attractive candidate for combinatory anti-cancer therapies. Despite its extensi...

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Bibliographic Details
Main Authors: Alexandr V. Bazhin, Katharina von Ahn, Jasmin Fritz, Jens Werner, Svetlana Karakhanova
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
PD-L1 (B7-H1)
immunosuppression
IFNα
cancer immunotherapy
dendritic cell
STAT3 signaling
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02129/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02129/full

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