Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children

Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children

Abstract Background Antibodies targeting Plasmodium falciparum sporozoites play a key role in human immunity to malaria. However, antibody mechanisms that neutralize sporozoites are poorly understood. This has been a major constraint in developing highly efficacious vaccines, as we lack strong corre...

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Bibliographic Details
Main Authors: Liriye Kurtovic, Marije C. Behet, Gaoqian Feng, Linda Reiling, Kiprotich Chelimo, Arlene E. Dent, Ivo Mueller, James W. Kazura, Robert W. Sauerwein, Freya J. I. Fowkes, James G. Beeson
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Medicine
Subjects:
Antibodies
Circumsporozoite protein
Sporozoite
Complement
Malaria
Plasmodium falciparum
Online Access:http://link.springer.com/article/10.1186/s12916-018-1054-2

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http://link.springer.com/article/10.1186/s12916-018-1054-2

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