Soluble Compounds Released by Hypoxic Stroma Confer Invasive Properties to Pancreatic Ductal Adenocarcinoma

Soluble Compounds Released by Hypoxic Stroma Confer Invasive Properties to Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma and a hypoxic microenvironment. Pancreatic stellate cells (PSC) are activated by hypoxia and promote excessive desmoplasia, further contributing to the development of hypoxia. We aimed to explore how hypoxia and stroma inter...

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Bibliographic Details
Main Authors: Dajia Liu, Anne Steins, Remy Klaassen, Amber P. van der Zalm, Roel J. Bennink, Geertjan van Tienhoven, Marc G. Besselink, Maarten F. Bijlsma, Hanneke W. M. van Laarhoven
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Biomedicines
Subjects:
epithelial-to-mesenchymal transition
hypoxia
pancreatic ductal adenocarcinoma
pancreatic stellate cells
stroma
Online Access:https://www.mdpi.com/2227-9059/8/11/444

Internet

https://www.mdpi.com/2227-9059/8/11/444

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