Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs

Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs

Abstract Background Mapping of allele-specific DNA methylation (ASM) can be a post-GWAS strategy for localizing regulatory sequence polymorphisms (rSNPs). The advantages of this approach, and the mechanisms underlying ASM in normal and neoplastic cells, remain to be clarified. Results We perform who...

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Bibliographic Details
Main Authors: Catherine Do, Emmanuel L. P. Dumont, Martha Salas, Angelica Castano, Huthayfa Mujahed, Leonel Maldonado, Arunjot Singh, Sonia C. DaSilva-Arnold, Govind Bhagat, Soren Lehman, Angela M. Christiano, Subha Madhavan, Peter L. Nagy, Peter H. R. Green, Rena Feinman, Cornelia Trimble, Nicholas P. Illsley, Karen Marder, Lawrence Honig, Catherine Monk, Andre Goy, Kar Chow, Samuel Goldlust, George Kaptain, David Siegel, Benjamin Tycko
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Genome Biology
Online Access:http://link.springer.com/article/10.1186/s13059-020-02059-3

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http://link.springer.com/article/10.1186/s13059-020-02059-3

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