(1R,5S)-6-(4-Methyl-2-oxo-2,5-dihydrofuran-3-yl)-3-phenyl-4-oxa-2,6-diazabicyclo[3.2.0]hept-2-en-7-one

(1R,5S)-6-(4-Methyl-2-oxo-2,5-dihydrofuran-3-yl)-3-phenyl-4-oxa-2,6-diazabicyclo[3.2.0]hept-2-en-7-one

Efficient large-scale and feasible industrial synthesis of the 1-oxacephem core structure from 6-aminopenicillanic acid (6-APA) has been reported for several decades. Via the industrial synthesis route, a byproduct (compound 9) containing a butenolide unit was purified and characterized by NMR and H...

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Bibliographic Details
Main Authors: Dong-Jun Fu, Victor Pham, Matthew-Alexander Tippin, Liankun Song, Xiaolin Zi, En Zhang, Hong-Min Liu
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Molbank
Subjects:
industrial feasible synthesis
6-APA
butenolide
1-oxacephem
Online Access:http://www.mdpi.com/1422-8599/2018/3/M1016

Internet

http://www.mdpi.com/1422-8599/2018/3/M1016

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