Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs.

Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs.

Two chemotypes were examined in vitro with CYPs 3A4 and 2C19 by molecular docking, metabolic profiles, and intrinsic clearance deuterium isotope effects with specifically deuterated form to assess the potential for enhancement of pharmacokinetic parameters. The results show the complexity of deutera...

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Bibliographic Details
Main Authors: Hao Sun, David W Piotrowski, Suvi T M Orr, Joseph S Warmus, Angela C Wolford, Steven B Coffey, Kentaro Futatsugi, Yinsheng Zhang, Alfin D N Vaz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6235261?pdf=render

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http://europepmc.org/articles/PMC6235261?pdf=render

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