Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase

Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase

Diabetic dyslipidemia requires simultaneous treatment with hypoglycemic agents and lipid-modulating drugs. We recently described glycogen phosphorylase inhibitors that reduce glycogenolysis in cells and lower plasma glucose in ob/ob mice (J. Med. Chem., 41: 2934, 1998). In evaluating the series prot...

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Bibliographic Details
Main Authors: H. James Harwood, Jr., Stephen F. Petras, Dennis J. Hoover, Dayna C. Mankowski, Victor F. Soliman, Eliot D. Sugarman, Bernard Hulin, Younggil Kwon, E. Michael Gibbs, James T. Mayne, Judith L. Treadway
Format: Article
Language:English
Published: Elsevier 2005-03-01
Series:Journal of Lipid Research
Subjects:
cholesterol synthesis
glycogenolysis
glycogen phosphorylase
lanosterol 14α-demethylase
CYP51
enzyme inhibition
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520340396

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http://www.sciencedirect.com/science/article/pii/S0022227520340396

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