Growth-coupled selection of synthetic modules to accelerate cell factory development

Synthetic biology has brought about a conceptual shift in our ability to redesign microbial metabolic networks. Combining metabolic pathway-modularization with growth-coupled selection schemes is a powerful tool that enables deep rewiring of the cell factories’ biochemistry for rational bioproductio...

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Bibliographic Details
Main Authors: Enrico Orsi, Nico J. Claassens, Pablo I. Nikel, Steffen N. Lindner
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25665-6