Dysregulation of Intestinal Epithelial Cell RIPK Pathways Promotes Chronic Inflammation in the IBD Gut

Crohn's disease (CD) and ulcerative colitis (UC) are common intestinal bowel diseases (IBD) characterized by intestinal epithelial injury including extensive epithelial cell death, mucosal erosion, ulceration, and crypt abscess formation. Several factors including activated signaling pathways,...

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Bibliographic Details
Main Authors: Ricard Garcia-Carbonell, Shih-Jing Yao, Soumita Das, Monica Guma
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
IBD
A20
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01094/full