rhACE2 Therapy Modifies Bleomycin-Induced Pulmonary Hypertension via Rescue of Vascular Remodeling

rhACE2 Therapy Modifies Bleomycin-Induced Pulmonary Hypertension via Rescue of Vascular Remodeling

Background: Pulmonary hypertension (PH) is a progressive cardiovascular disease, characterized by endothelial and smooth muscle dysfunction and vascular remodeling, followed by right heart failure. Group III PH develops secondarily to chronic lung disease such as idiopathic pulmonary fibrosis (IPF),...

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Bibliographic Details
Main Authors: Anandharajan Rathinasabapathy, Andrew J. Bryant, Toshio Suzuki, Christy Moore, Sheila Shay, Santhi Gladson, James D. West, Erica J. Carrier
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Physiology
Subjects:
pulmonary hypertension
pulmonary fibrosis
ACE2
bleomycin
mice
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00271/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2018.00271/full

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