Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression

Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression

Abstract Background Multiple sclerosis (MS) is a chronic immune-mediated disorder of the central nervous system characterized by demyelination, neuroinflammation, and neurodegeneration. Activation of the kynurenine pathway (KP) results from acute and chronic neuroinflammation leading to both immune...

Full description

Bibliographic Details
Main Authors: Gayathri Sundaram, Chai K. Lim, Bruce J. Brew, Gilles J. Guillemin
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Neuroinflammation
Subjects:
Multiple sclerosis
Tryptophan
Kynurenine pathway
Quinolinic acid
Neuroinflammation
Neurodegeneration
Online Access:http://link.springer.com/article/10.1186/s12974-020-01844-y

Internet

http://link.springer.com/article/10.1186/s12974-020-01844-y

Similar Items