Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease

Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease

Current research on Parkinson's disease (PD) pathogenesis requires relevant animal models that mimic the gradual and progressive development of neuronal dysfunction and degeneration that characterizes the disease. Polymorphisms in engrailed 1 (En1), a homeobox transcription factor that is cruci...

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Bibliographic Details
Main Authors: Ulrika Nordström, Geneviève Beauvais, Anamitra Ghosh, Baby Chakrapani Pulikkaparambil Sasidharan, Martin Lundblad, Julia Fuchs, Rajiv L. Joshi, Jack W. Lipton, Andrew Roholt, Satish Medicetty, Timothy N. Feinstein, Jennifer A. Steiner, Martha L. Escobar Galvis, Alain Prochiantz, Patrik Brundin
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Neurobiology of Disease
Subjects:
Retrograde degeneration
TH–GFP
En1+/− mice
CLARITY
In vivo electrochemistry
Impaired dopamine release
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114002848

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http://www.sciencedirect.com/science/article/pii/S0969996114002848

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