Biotechnological and Immunological Platforms Based on PGL-I Carbohydrate-Like Peptide of Mycobacterium leprae for Antibodies Detection Among Leprosy Clinical Forms

Biotechnological and Immunological Platforms Based on PGL-I Carbohydrate-Like Peptide of Mycobacterium leprae for Antibodies Detection Among Leprosy Clinical Forms

Phenolic glycolipid I (PGL-I) is an abundant antigen on the Mycobacterium leprae cell wall, commonly used for operational classification of leprosy patients. Our aim was to develop PGL-I mimotopes with similar characteristics and functions of the native antigen. We have used a random peptide phage d...

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Bibliographic Details
Main Authors: Mayara Ingrid Sousa Lima, Fausto Emilio Capparelli, Jaqueline das Dores Dias Oliveira, Patrícia Tiemi Fujimura, Emilly Caroline dos Santos Moraes, Ester Cristina Borges Araujo, Neide Maria Silva, Renata Pereira Alves-Balvedi, Ana Graci Brito-Madurro, Isabela Maria Bernardes Goulart, Luiz Ricardo Goulart
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Microbiology
Subjects:
phenolic glycolipid I
mimotopes
phage display
scFv
ELISA
surface plasmon resonance
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00429/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.00429/full

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