CD4+ T cell-derived IL-10 promotes Brucella abortus persistence via modulation of macrophage function.

CD4+ T cell-derived IL-10 promotes Brucella abortus persistence via modulation of macrophage function.

Evasion of host immune responses is a prerequisite for chronic bacterial diseases; however, the underlying mechanisms are not fully understood. Here, we show that the persistent intracellular pathogen Brucella abortus prevents immune activation of macrophages by inducing CD4(+)CD25(+) T cells to pro...

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Bibliographic Details
Main Authors: Mariana N Xavier, Maria G Winter, Alanna M Spees, Kim Nguyen, Vidya L Atluri, Teane M A Silva, Andreas J Bäumler, Werner Müller, Renato L Santos, Renée M Tsolis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3688575?pdf=render

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http://europepmc.org/articles/PMC3688575?pdf=render

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