The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes

The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes

Mammals store metabolic energy as triacylglycerols (TGs) in adipose tissue. TG synthesis is catalyzed by the evolutionarily unrelated acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes DGAT1 and DGAT2, which catalyze the same reaction and account for nearly all TG synthesis. The reasons for thei...

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Bibliographic Details
Main Authors: Chandramohan Chitraju, Tobias C. Walther, Robert V. Farese, Jr.
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Journal of Lipid Research
Subjects:
adipose tissue
diacylglycerol acyltransferase
high-fat diet
induced obesity
glucose intolerance
endoplasmic reticulum stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520322513

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http://www.sciencedirect.com/science/article/pii/S0022227520322513

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