BTLA-Expressing Dendritic Cells in Patients With Tuberculosis Exhibit Reduced Production of IL-12/IFN-α and Increased Production of IL-4 and TGF-β, Favoring Th2 and Foxp3+ Treg Polarization

BTLA-Expressing Dendritic Cells in Patients With Tuberculosis Exhibit Reduced Production of IL-12/IFN-α and Increased Production of IL-4 and TGF-β, Favoring Th2 and Foxp3+ Treg Polarization

Little is known about how tuberculosis (TB) impairs dendritic cell (DC) function and anti-TB immune responses. We previously showed that the B and T lymphocyte attenuator (BTLA), an immune inhibitory receptor, is involved in TB pathogenesis. Here, we examined whether BTLA expression in TB affects ph...

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Bibliographic Details
Main Authors: Jun-Ai Zhang, Yuan-Bin Lu, Wan-Dang Wang, Gan-Bin Liu, Chen Chen, Ling Shen, Hou-Long Luo, Huan Xu, Ying Peng, Hong Luo, Gui-Xian Huang, Du-Du Wu, Bi-Ying Zheng, Lai-Long Yi, Zheng W. Chen, Jun-Fa Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
B and T lymphocyte attenuator
dendritic cells
IL-12
IFN-α
CD4+ T cell
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00518/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.00518/full

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