Neoantimycin F, a Streptomyces-Derived Natural Product Induces Mitochondria-Related Apoptotic Death in Human Non-Small Cell Lung Cancer Cells

Neoantimycin F, a Streptomyces-Derived Natural Product Induces Mitochondria-Related Apoptotic Death in Human Non-Small Cell Lung Cancer Cells

Streptomyces-derived natural products have been become a major focus of anti-tumor drug discovery studies. Neoantimycin F (NAT-F), was isolated from Streptomyces conglobatus by our group. Here, we examined the anti-cancer activities and its underlying molecular mechanisms implicated in NAT-F–induced...

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Bibliographic Details
Main Authors: Liyun Liu, Hongrui Zhu, Wei Wu, Yaoyao Shen, Xiao Lin, Ying Wu, Li Liu, Jie Tang, Yongjun Zhou, Fan Sun, Hou-Wen Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
non-small cell lung cancer (NSCLC)
neoantimycin F
cell cycle
apoptosis
MMP
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01042/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01042/full

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