Induction of ATP Release, PPIX Transport, and Cholesterol Uptake by Human Red Blood Cells Using a New Family of TSPO Ligands

Induction of ATP Release, PPIX Transport, and Cholesterol Uptake by Human Red Blood Cells Using a New Family of TSPO Ligands

Two main isoforms of the Translocator Protein (TSPO) have been identified. TSPO1 is ubiquitous and is mainly present at the outer mitochondrial membrane of most eukaryotic cells, whereas, TSPO2 is specific to the erythroid lineage, located at the plasma membrane, the nucleus, and the endoplasmic ret...

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Bibliographic Details
Main Authors: Irene Marginedas-Freixa, Cora L. Alvarez, Martina Moras, Claude Hattab, Guillaume Bouyer, Arnaud Chene, Sophie D. Lefevre, Caroline Le Van Kim, Frederic Bihel, Pablo J. Schwarzbaum, Mariano A. Ostuni
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:International Journal of Molecular Sciences
Subjects:
TSPO
TSPO2
red blood cell
erythrocyte
ATP
ZnPPIX
plasmodium
malaria
VDAC
Online Access:http://www.mdpi.com/1422-0067/19/10/3098

Internet

http://www.mdpi.com/1422-0067/19/10/3098

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