Chaperone-Targeting Cytotoxin and Endoplasmic Reticulum Stress-Inducing Drug Synergize to Kill Cancer Cells

Chaperone-Targeting Cytotoxin and Endoplasmic Reticulum Stress-Inducing Drug Synergize to Kill Cancer Cells

Diverse physiological and therapeutic insults that increase the amount of unfolded or misfolded proteins in the endoplasmic reticulum (ER) induce the unfolded protein response, an evolutionarily conserved protective mechanism that manages ER stress. Glucose-regulated protein 78/immunoglobulin heavy...

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Bibliographic Details
Main Authors: Joseph M. Backer, Arcadius V. Krivoshein, Carl V. Hamby, John Pizzonia, Kenneth S. Gilbert, Yonaton S. Ray, Harrison Brand, Adrienne W. Paton, James C. Paton, Marina V. Backer
Format: Article
Language:English
Published: Elsevier 2009-11-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558609800742

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http://www.sciencedirect.com/science/article/pii/S1476558609800742

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