Acute EPA-induced learning and memory impairment in mice is prevented by DHA

Acute EPA-induced learning and memory impairment in mice is prevented by DHA

Acute administration of EPA impairs learning and memory and hippocampal LTP in mice that was mediated through enhancing GABAergic transmission via the 5-HT6R. DHA can prevent EPA-induced impairments at a ratio of EPA to DHA similar to that in marine fish oil via the 5-HT2CR.

Bibliographic Details
Main Authors: Ji-Hong Liu, Qian Wang, Qiang-Long You, Ze-Lin Li, Neng-Yuan Hu, Yan Wang, Zeng-Lin Jin, Shu-Ji Li, Xiao-Wen Li, Jian-Ming Yang, Xin-Hong Zhu, Yi-Fan Dai, Jiang-Ping Xu, Xiao-Chun Bai, Tian-Ming Gao
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19255-1

Internet

https://doi.org/10.1038/s41467-020-19255-1

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