Mechanisms of telomere maintenance in pediatric brain tumors: Promising targets for therapy – A narrative review

Mechanisms of telomere maintenance in pediatric brain tumors: Promising targets for therapy – A narrative review

Recent advances in genetic and molecular characterization of telomere maintenance mechanisms (TMMs) highlighted their strong relationship with cancer pathogenesis; neoplastic cells rely on two mechanisms to maintain telomere length and escape from replicative senescence: (a) reactivation of telomera...

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Bibliographic Details
Main Authors: Simone Minasi, Francesca Gianno, Hiba Alzoubi, Manila Antonelli, Felice Giangaspero, Francesca Romana Buttarelli
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Glioma
Subjects:
alpha-thalassemia/mental retardation syndrome x-linked
alternative lengthening of telomere
antialternative lengthening of telomere therapy
antitelomerase therapy
glioma
h3.3
medulloblastoma
pediatric brain tumors
telomerase reverse transcriptase
telomerase
Online Access:http://www.jglioma.com/article.asp?issn=2589-6113;year=2020;volume=3;issue=3;spage=105;epage=118;aulast=Minasi

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http://www.jglioma.com/article.asp?issn=2589-6113;year=2020;volume=3;issue=3;spage=105;epage=118;aulast=Minasi

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