In vitro schistosomicidal activity of the lignan (−)-6,6′-dinitrohinokinin (DNHK) loaded into poly(lactic-co-glycolic acid) nanoparticles against Schistosoma mansoni

In vitro schistosomicidal activity of the lignan (−)-6,6′-dinitrohinokinin (DNHK) loaded into poly(lactic-co-glycolic acid) nanoparticles against Schistosoma mansoni

Context: (−)-6,6′-Dinitrohinokinin (DNHK) display remarkable antiparasitic activity and was, therefore, incorporated into a nanoparticle formulation. Objective: Incorporation of DNHK in poly lactic-co-glycolic acid (PLGA) nanoparticles aiming to improve its biological activities. Materials and metho...

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Bibliographic Details
Main Authors: Thaís C. Lima, Rodrigo Lucarini, Priscilla P. Luz, Emerson H. de Faria, Liziane Marçal, Lizandra G. Magalhães, Fernanda R. Badoco, Viviane R. Esperandim, Eduardo F. Molina, Rosangela S. Laurentz, Regiane G. Lima, Wilson R. Cunha, Jairo K. Bastos, Marcio L. Andrade Silva
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Pharmaceutical Biology
Subjects:
plga
biological activity
nanoparticulate formulation
6,6′-dinitrohinokinin
schistosomicidal
Online Access:http://dx.doi.org/10.1080/13880209.2017.1405996

Internet

http://dx.doi.org/10.1080/13880209.2017.1405996

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