Role of Endothelium in Doxorubicin-Induced Cardiomyopathy

Summary: The clinical use of doxorubicin in cancer is limited by cardiotoxic effects that can lead to heart failure. Whereas earlier work focused on the direct impact of doxorubicin on cardiomyocytes, recent studies have turned to the endothelium, because doxorubicin-damaged endothelial cells can tr...

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Bibliographic Details
Main Authors: Albert Z. Luu, BSc, Biswajit Chowdhury, PhD, Mohammed Al-Omran, MD, MSc, Hwee Teoh, PhD, David A. Hess, PhD, Subodh Verma, MD, PhD
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X18301396