Critical roles for LIGHT and its receptors in generating T cell-mediated immunity during Leishmania donovani infection.

Critical roles for LIGHT and its receptors in generating T cell-mediated immunity during Leishmania donovani infection.

LIGHT (TNFSF14) is a member of the TNF superfamily involved in inflammation and defence against infection. LIGHT signals via two cell-bound receptors; herpes virus entry mediator (HVEM) and lymphotoxin-beta receptor (LTβR). We found that LIGHT is critical for control of hepatic parasite growth in mi...

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Bibliographic Details
Main Authors: Amanda C Stanley, Fabian de Labastida Rivera, Ashraful Haque, Meru Sheel, Yonghong Zhou, Fiona H Amante, Patrick T Bunn, Louise M Randall, Klaus Pfeffer, Stefanie Scheu, Michael J Hickey, Bernadette M Saunders, Carl Ware, Geoff R Hill, Koji Tamada, Paul M Kaye, Christian R Engwerda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-10-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21998581/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21998581/?tool=EBI

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