IgG-Independent Co-aggregation of FcεRI and FcγRIIB Results in LYN- and SHIP1-Dependent Tyrosine Phosphorylation of FcγRIIB in Murine Bone Marrow-Derived Mast Cells

IgG-Independent Co-aggregation of FcεRI and FcγRIIB Results in LYN- and SHIP1-Dependent Tyrosine Phosphorylation of FcγRIIB in Murine Bone Marrow-Derived Mast Cells

Activation of the high-affinity receptor for IgE (FcεRI) follows a bell-shaped dose-response curve. Upon supra-optimal stimulation, mast cell effector responses are down-regulated by inhibitory molecules like the SH2-containing inositol-5′-phosphatase SHIP1 and the SRC-family-kinase LYN. To identify...

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Bibliographic Details
Main Authors: Mathias Gast, Christian Preisinger, Falk Nimmerjahn, Michael Huber
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
dose-response
Fc receptor
phospho-proteomics
submembranous cytoskeleton
SHIP1 recruitment
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01937/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01937/full

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