SP600125 enhances C-2-induced cell death by the switch from autophagy to apoptosis in bladder cancer cells

SP600125 enhances C-2-induced cell death by the switch from autophagy to apoptosis in bladder cancer cells

Abstract Background A natural compound Jaspine B and its derivative possess potential anti-cancer activities; However, little is known about the underlying mechanism. Here, the role of a new autophagy inducer Jaspine B derivative C-2 in suppressing bladder cancer cells was researched in vitro and in...

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Bibliographic Details
Main Authors: Haiyang Yu, Chun-Li Wu, Xiangyu Wang, Qianhong Ban, Chunhua Quan, Mengbo Liu, Hangqi Dong, Jinfeng Li, Gi-Young Kim, Yung Hyun Choi, Zhenya Wang, Cheng-Yun Jin
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
SP600125
Autophagy
Apoptosis
Bladder cancer
C-2
SQSTM1/p62
Online Access:http://link.springer.com/article/10.1186/s13046-019-1467-6

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http://link.springer.com/article/10.1186/s13046-019-1467-6

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