<i>CDH1</i> Gene Mutation Hereditary Diffuse Gastric Cancer Outcomes: Analysis of a Large Cohort, Systematic Review of Endoscopic Surveillance, and Secondary Cancer Risk Postulation

<i>CDH1</i> Gene Mutation Hereditary Diffuse Gastric Cancer Outcomes: Analysis of a Large Cohort, Systematic Review of Endoscopic Surveillance, and Secondary Cancer Risk Postulation

Hereditary diffuse gastric cancer (HDGC) is a rare signet-ring cell adenocarcinoma (SRCC) linked to <i>CDH1</i> (E-cadherin) inactivating germline mutations, and increasingly other gene mutations. Female <i>CDH1</i> mutation carriers have additional risk of lobular breast can...

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Bibliographic Details
Main Authors: Matthew G. K. Benesch, Stuart R. Bursey, Andrew C. O’Connell, Morag G. Ryan, Carrie L. Howard, Cecily C. Stockley, Alexander Mathieson
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
<i>CDH1</i>
E-cadherin
mutation
gastric cancer
lobular breast cancer
Cambridge Protocol
Online Access:https://www.mdpi.com/2072-6694/13/11/2622

Internet

https://www.mdpi.com/2072-6694/13/11/2622

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