Revealing the Effects of Missense Mutations Causing Snyder-Robinson Syndrome on the Stability and Dimerization of Spermine Synthase

Revealing the Effects of Missense Mutations Causing Snyder-Robinson Syndrome on the Stability and Dimerization of Spermine Synthase

Missense mutations in spermine synthase (SpmSyn) protein have been shown to cause the Snyder-Robinson syndrome (SRS). Depending on the location within the structure of SpmSyn and type of amino acid substitution, different mechanisms resulting in SRS were proposed. Here we focus on naturally occurrin...

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Bibliographic Details
Main Authors: Yunhui Peng, Joy Norris, Charles Schwartz, Emil Alexov
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:International Journal of Molecular Sciences
Subjects:
missense mutation
energy calculations
Snyder-Robinson syndrome
spermine synthase
binding affinity charge
Online Access:http://www.mdpi.com/1422-0067/17/1/77

Internet

http://www.mdpi.com/1422-0067/17/1/77

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