Mutation-specific non-canonical pathway of PTEN as a distinct therapeutic target for glioblastoma

Mutation-specific non-canonical pathway of PTEN as a distinct therapeutic target for glioblastoma

Abstract PTEN is one of the most frequently altered tumor suppressor genes in malignant tumors. The dominant-negative effect of PTEN alteration suggests that the aberrant function of PTEN mutation might be more disastrous than deletion, the most frequent genomic event in glioblastoma (GBM). This stu...

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Bibliographic Details
Main Authors: Seung Won Choi, Yeri Lee, Kayoung Shin, Harim Koo, Donggeon Kim, Jason K. Sa, Hee Jin Cho, Hye-mi Shin, Se Jeong Lee, Hyunho Kim, Seok Chung, Jihye Shin, Cheolju Lee, Do-Hyun Nam
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03657-0

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https://doi.org/10.1038/s41419-021-03657-0

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