Biomarkers allow detection of nutrient limitations and respective supplementation for elimination in Pichia pastoris fed-batch cultures

Biomarkers allow detection of nutrient limitations and respective supplementation for elimination in Pichia pastoris fed-batch cultures

Abstract Background Industrial processes for recombinant protein production challenge production hosts, such as the yeast Pichia pastoris, on multiple levels. During a common P. pastoris fed-batch process, cells experience strong adaptations to different metabolic states or suffer from environmental...

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Bibliographic Details
Main Authors: Jonas Burgard, Minoska Valli, Alexandra B. Graf, Brigitte Gasser, Diethard Mattanovich
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Microbial Cell Factories
Subjects:
Pichia pastoris
Yeast
Transcriptional regulation
Fed batch cultivation
Transcriptomics
Media optimization
Online Access:http://link.springer.com/article/10.1186/s12934-017-0730-9

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http://link.springer.com/article/10.1186/s12934-017-0730-9

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