Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies

Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies

We describe the synthesis, reactivity, and antithrombotic and anti-angiogenesis activity of difluoroallicin (S-(2-fluoroallyl) 2-fluoroprop-2-ene-1-sulfinothioate) and S-2-fluoro-2-propenyl-l-cysteine, both easily prepared from commercially available 3-chloro-2-fluoroprop-1-ene, as well as the synth...

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Bibliographic Details
Main Authors: Eric Block, Benjamin Bechand, Sivaji Gundala, Abith Vattekkatte, Kai Wang, Shaymaa S. Mousa, Kavitha Godugu, Murat Yalcin, Shaker A. Mousa
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Molecules
Subjects:
garlic
allicin
vinyl dithiins
ajoene
difluoroallicin
trifluoroajoene
angiogenesis
anti-angiogenesis
platelet
coagulation
thrombosis
anti-thrombotic
2-fluoroallyl sulfur compounds
Online Access:https://www.mdpi.com/1420-3049/22/12/2081

Internet

https://www.mdpi.com/1420-3049/22/12/2081

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