Entry of Polarized Effector Cells into Quiescence Forces HIV Latency

Entry of Polarized Effector Cells into Quiescence Forces HIV Latency

Current primary cell models for HIV latency correlate poorly with the reactivation behavior of patient cells. We have developed a new model, called QUECEL, which generates a large and homogenous population of latently infected CD4+ memory cells. By purifying HIV-infected cells and inducing cell quie...

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Bibliographic Details
Main Authors: Curtis Dobrowolski, Saba Valadkhan, Amy C. Graham, Meenakshi Shukla, Angela Ciuffi, Amalio Telenti, Jonathan Karn
Format: Article
Language:English
Published: American Society for Microbiology 2019-03-01
Series:mBio
Subjects:
cell quiescence
HIV latency
HIV reservoir
P-TEFb
human immunodeficiency virus
Online Access:https://doi.org/10.1128/mBio.00337-19

Internet

https://doi.org/10.1128/mBio.00337-19

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