Entry of Polarized Effector Cells into Quiescence Forces HIV Latency

Current primary cell models for HIV latency correlate poorly with the reactivation behavior of patient cells. We have developed a new model, called QUECEL, which generates a large and homogenous population of latently infected CD4+ memory cells. By purifying HIV-infected cells and inducing cell quie...

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Bibliographic Details
Main Authors: Curtis Dobrowolski, Saba Valadkhan, Amy C. Graham, Meenakshi Shukla, Angela Ciuffi, Amalio Telenti, Jonathan Karn
Format: Article
Language:English
Published: American Society for Microbiology 2019-03-01
Series:mBio
Subjects:
Online Access:https://doi.org/10.1128/mBio.00337-19