DNA Damage Response and Repair Gene Alterations Increase Tumor Mutational Burden and Promote Poor Prognosis of Advanced Lung Cancer

DNA Damage Response and Repair Gene Alterations Increase Tumor Mutational Burden and Promote Poor Prognosis of Advanced Lung Cancer

DNA damage response and repair (DDR) gene alterations increase tumor-infiltrating lymphocytes, genomic instability, and tumor mutational burden (TMB). Whether DDR-related alterations relate to therapeutic response and prognosis in lung cancer lacking oncogenic drivers remains unknown. Pretherapeutic...

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Bibliographic Details
Main Authors: Jiawei Dai, Minlin Jiang, Kan He, Hao Wang, Peixin Chen, Haoyue Guo, Wencheng Zhao, Hui Lu, Yayi He, Caicun Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Oncology
Subjects:
DNA damage and repair
DDR
tumor mutational burden
tumor microenvironment
immune infiltration
heterogeneity
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.708294/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.708294/full

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