Spatiotemporal Mapping Techniques Show Clozapine Impairs Neurogenic and Myogenic Patterns of Activity in the Colon of the Rabbit in a Dose-Dependent Manner

Spatiotemporal Mapping Techniques Show Clozapine Impairs Neurogenic and Myogenic Patterns of Activity in the Colon of the Rabbit in a Dose-Dependent Manner

Background: Clozapine, an antipsychotic used in treatment-resistant schizophrenia, has adverse gastrointestinal effects with significant associated morbidity and mortality. However, its effects on defined patterns of colonic contractile activity have not been assessed.Method: We used novel radial an...

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Bibliographic Details
Main Authors: Roger G. Lentle, Susanna Every-Palmer, Gordon Reynolds, Corrin Hulls, Paul Chambers, Helen Dunn, Pete M. Ellis
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Pharmacology
Subjects:
clozapine
antipsychotic agents
gastrointestinal motility
gastrointestinal tract
constipation
ileus
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00209/full

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http://journal.frontiersin.org/article/10.3389/fphar.2017.00209/full

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