Structural basis of enzyme activity regulation by the propeptide of l-lysine α-oxidase precursor from Trichoderma viride

Structural basis of enzyme activity regulation by the propeptide of l-lysine α-oxidase precursor from Trichoderma viride

Harmuful proteins are usually synthesized as inactive precursors and are activated by proteolytic processing. l-Amino acid oxidase (LAAO) is a flavoenzyme that catalyzes the oxidative deamination of l-amino acid to produce a 2-oxo acid with ammonia and highly toxic hydrogen peroxide and, therefore,...

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Bibliographic Details
Main Authors: Masaki Kitagawa, Nanako Ito, Yuya Matsumoto, Masaya Saito, Takashi Tamura, Hitoshi Kusakabe, Kenji Inagaki, Katsumi Imada
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Structural Biology: X
Subjects:
L-Lysine α-oxidase
Crystal structure
Precursor
Substrate recognition
Online Access:http://www.sciencedirect.com/science/article/pii/S2590152421000015

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http://www.sciencedirect.com/science/article/pii/S2590152421000015

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