A transcriptome-based classifier to determine molecular subtypes in medulloblastoma.

A transcriptome-based classifier to determine molecular subtypes in medulloblastoma.

Medulloblastoma is a highly heterogeneous pediatric brain tumor with five molecular subtypes, Sonic Hedgehog TP53-mutant, Sonic Hedgehog TP53-wildtype, WNT, Group 3, and Group 4, defined by the World Health Organization. The current mechanism for classification into these molecular subtypes is throu...

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Bibliographic Details
Main Authors: Komal S Rathi, Sherjeel Arif, Mateusz Koptyra, Ammar S Naqvi, Deanne M Taylor, Phillip B Storm, Adam C Resnick, Jo Lynne Rokita, Pichai Raman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-10-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1008263

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https://doi.org/10.1371/journal.pcbi.1008263

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