Systematic generation of biophysically detailed models for diverse cortical neuron types

Systematic generation of biophysically detailed models for diverse cortical neuron types

Neocortical circuits exhibit diverse cell types that can be difficult to build into computational models. Here the authors employ a genetic algorithm-based parameter optimization to generate multi-compartment Hodgkin-Huxley models for diverse cell types in the Allen Cell Types Database.

Bibliographic Details
Main Authors: Nathan W. Gouwens, Jim Berg, David Feng, Staci A. Sorensen, Hongkui Zeng, Michael J. Hawrylycz, Christof Koch, Anton Arkhipov
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02718-3

Internet

https://doi.org/10.1038/s41467-017-02718-3

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