Importance of the α10 helix for DevR activation: A road map for screening inhibitors against DevR-mediated dormancy of Mycobacterium tuberculosis

Importance of the α10 helix for DevR activation: A road map for screening inhibitors against DevR-mediated dormancy of Mycobacterium tuberculosis

Objective/Background: Bacterial persistence is the hallmark of tuberculosis (TB) and poses the biggest threat to the success of any antitubercular drug regimen. The DevR/DosR dormancy regulator of Mycobacterium tuberculosis belongs to the NarL subfamily of response regulators and is essential for M....

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Bibliographic Details
Main Authors: Atul Vashist, D Prithvi Raj, Umesh Datta Gupta, Rajiv Bhat, Jaya Sivaswami Tyagi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2016-01-01
Series:International Journal of Mycobacteriology
Subjects:
Dormancy
Hypoxia
Mycobacterium tuberculosis
Phosphorylation
Two-component signal transduction system
Online Access:http://www.ijmyco.org/article.asp?issn=2212-5531;year=2016;volume=5;issue=5;spage=92;epage=93;aulast=Vashist

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http://www.ijmyco.org/article.asp?issn=2212-5531;year=2016;volume=5;issue=5;spage=92;epage=93;aulast=Vashist

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