A frame-shifted gene, which rescued its function by non-natural start codons and its application in constructing synthetic gene circuits

A frame-shifted gene, which rescued its function by non-natural start codons and its application in constructing synthetic gene circuits

Abstract Background Frame-shifted genes results in non-functional peptides. Because of this complete loss of function, frame-shifted genes have never been used in constructing synthetic gene circuits. Results Here we report that the function of gene circuits is rescued by a frame-shifted gene, which...

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Bibliographic Details
Main Authors: Kathakali Sarkar, Sayak Mukhopadhyay, Deepro Bonnerjee, Rajkamal Srivastava, Sangram Bagh
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Biological Engineering
Subjects:
Frame-shifted gene
Non-natural start codons
Rescued function
Synthetic gene circuits
E. coli
Non-directed evolution of synthetic gene circuit
Online Access:http://link.springer.com/article/10.1186/s13036-019-0151-x

Internet

http://link.springer.com/article/10.1186/s13036-019-0151-x

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