Effects of the selective GPER1 agonist G1 on bone growth

Estrogens may affect bone growth locally or systemically via the known estrogen receptors ESR1, ESR2 and G protein-coupled estrogen receptor 1 (GPER1). Mouse and human growth plate chondrocytes have been demonstrated to express GPER1 and ablation of this receptor increased bone length in mice. There...

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Bibliographic Details
Main Authors: Maryam Iravani, Marie K Lagerquist, Elham Karimian, Andrei S Chagin, Claes Ohlsson, Lars Sävendahl
Format: Article
Language:English
Published: Bioscientifica 2019-09-01
Series:Endocrine Connections
Subjects:
G1
Online Access:https://ec.bioscientifica.com/view/journals/ec/aop/ec-19-0274.xml