Pro-Inflammatory Stimuli Influence Expression of Intercellular Adhesion Molecule 1 in Human Anulus Fibrosus Cells through FAK/ERK/GSK3 and PKCδ Signaling Pathways

Pro-Inflammatory Stimuli Influence Expression of Intercellular Adhesion Molecule 1 in Human Anulus Fibrosus Cells through FAK/ERK/GSK3 and PKCδ Signaling Pathways

Objective: Intervertebral disc (IVD) degeneration and disc herniation are major causes of lower back pain, which involve the presence of inflammatory mediators and tissue invasion by immune cells. Intercellular adhesion molecule 1 (ICAM1, also termed CD54) is an adhesion molecule that mediates cell-...

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Bibliographic Details
Main Authors: Bor-Ren Huang, Da-Tian Bau, Tzu-Sheng Chen, I-Chen Chuang, Cheng-Fang Tsai, Pei-Chun Chang, Horng-Chaung Hsu, Dah-Yuu Lu
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:International Journal of Molecular Sciences
Subjects:
intervertebral disc
degeneration
anulus fibrosus
CCL2
ICAM1
Online Access:http://www.mdpi.com/1422-0067/20/1/77

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http://www.mdpi.com/1422-0067/20/1/77

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