Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures

Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures

Summary: CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is the most common form of genetic stroke and vascular dementia syndrome resulting from mutations in NOTCH3. To elucidate molecular mechanisms of the condition and identify drug targets, we...

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Main Authors: Joseph Kelleher, Adam Dickinson, Stuart Cain, Yanhua Hu, Nicola Bates, Adam Harvey, Jianzhen Ren, Wenjun Zhang, Fiona C. Moreton, Keith W. Muir, Christopher Ward, Rhian M. Touyz, Pankaj Sharma, Qingbo Xu, Susan J. Kimber, Tao Wang
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671119303650

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http://www.sciencedirect.com/science/article/pii/S2213671119303650

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