Triacylglycerols sequester monotopic membrane proteins to lipid droplets

Triacylglycerols (TG) are synthesized at the endoplasmic reticulum (ER) bilayer and packaged into monolayer lipid droplets (LDs), but how proteins partition between ER and LDs is poorly understood. Here authors use synthetic model systems and find that proteins containing hydrophobic membrane associ...

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Bibliographic Details
Main Authors: Lucie Caillon, Vincent Nieto, Pauline Gehan, Mohyeddine Omrane, Nicolas Rodriguez, Luca Monticelli, Abdou Rachid Thiam
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17585-8