SGLT1 Knockdown Attenuates Cardiac Fibroblast Activation in Diabetic Cardiac Fibrosis

SGLT1 Knockdown Attenuates Cardiac Fibroblast Activation in Diabetic Cardiac Fibrosis

Background: Cardiac fibroblast (CF) activation is a hallmark feature of cardiac fibrosis in diabetic cardiomyopathy (DCM). Inhibition of the sodium-dependent glucose transporter 1 (SGLT1) attenuates cardiomyocyte apoptosis and delays the development of DCM. However, the role of SGLT1 in CF activatio...

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Bibliographic Details
Main Authors: Hui Lin, Le Guan, Liping Meng, Hiroyasu Uzui, Hangyuan Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
cardiac fibroblasts
sodium–glucose cotransporter
high glucose
diabetic cardiomyopathy
mitogen-activated protein kinase
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.700366/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.700366/full

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