Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses

Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses

Emerging evidence supports the hypothesis that pathogenic protein aggregates associated with neurodegenerative diseases spread from cell to cell through the brain in a manner akin to infectious prions. Here, we show that mutant huntingtin (mHtt) aggregates associated with Huntington disease transfer...

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Bibliographic Details
Main Authors: Kirby M Donnelly, Olivia R DeLorenzo, Aprem DA Zaya, Gabrielle E Pisano, Wint M Thu, Liqun Luo, Ron R Kopito, Margaret M Panning Pearce
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
huntingtin
prion-like
neurodegeneration
phagocytic glia
Draper
protein aggregate
Online Access:https://elifesciences.org/articles/58499

Internet

https://elifesciences.org/articles/58499

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