Influence of Fibroblasts on Mammary Gland Development, Breast Cancer Microenvironment Remodeling, and Cancer Cell Dissemination

Influence of Fibroblasts on Mammary Gland Development, Breast Cancer Microenvironment Remodeling, and Cancer Cell Dissemination

The stromal microenvironment regulates mammary gland development and tumorigenesis. In normal mammary glands, the stromal microenvironment encompasses the ducts and contains fibroblasts, the main regulators of branching morphogenesis. Understanding the way fibroblast signaling pathways regulate mamm...

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Bibliographic Details
Main Authors: Angelica Avagliano, Giuseppe Fiume, Maria Rosaria Ruocco, Nunzia Martucci, Eleonora Vecchio, Luigi Insabato, Daniela Russo, Antonello Accurso, Stefania Masone, Stefania Montagnani, Alessandro Arcucci
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
fibroblasts
breast cancer associated fibroblasts (BCAFs)
mammary gland
breast cancer microenvironment
ECM remodeling
metastasis
Online Access:https://www.mdpi.com/2072-6694/12/6/1697

Internet

https://www.mdpi.com/2072-6694/12/6/1697

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