C1-Inhibitor protects from focal brain trauma in a cortical cryolesion mice model by reducing thrombo-inflammation

C1-Inhibitor protects from focal brain trauma in a cortical cryolesion mice model by reducing thrombo-inflammation

Traumatic brain injury (TBI) induces a strong inflammatory response which includes blood-brain barrier damage, edema formation and infiltration of different immune cell subsets. More recently, microvascular thrombosis has been identified as another pathophysiological feature of TBI. The contact-kini...

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Bibliographic Details
Main Authors: Christiane eAlbert-Weissenberger, Stine eMencl, Michael K. Schuhmann, Irmak eSalur, Eva eGöb, Friederike eLangenhauser, Sarah eHopp, Nelli eHennig, Sven G Meuth, Marc W. Nolte, Anna-Leena eSirén, Christoph eKleinschnitz
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Blood-Brain Barrier
Edema
Inflammation
Thrombosis
Traumatic Brain Injury
C1-Inhibitor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00269/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00269/full

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