Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

Secreted amyloid precursor protein-α (sAPPα) levels are reduced during the pathogenesis of Alzheimer's disease, but the significance of this for neural function is not well understood. Here, we show that intrahippocampal infusion of antibodies targeted to endogenous sAPPα reduced long-term pote...

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Bibliographic Details
Main Authors: Chanel J. Taylor, David R. Ireland, Irene Ballagh, Katie Bourne, Nicola M. Marechal, Paul R. Turner, David K. Bilkey, Warren P. Tate, Wickliffe C. Abraham
Format: Article
Language:English
Published: Elsevier 2008-08-01
Series:Neurobiology of Disease
Subjects:
Secreted APPα
Secreted APPβ
Long-term potentiation
NMDA receptor
AMPA receptor
Dentate gyrus
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108000880

Internet

http://www.sciencedirect.com/science/article/pii/S0969996108000880

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